I've run into it [1]. Try running your app from a local server.
You might also want to check out Chrome's debug version which doesn't seem to mind local files. It's not 100% stable but it does work most of the time... [1] http://apache-flex-users.2333346.n4.nabble.com/Can-t-Debug-From-Flash-Builder-td15724.html -- Sent from: http://apache-flex-users.2333346.n4.nabble.com/