> Is it possible to use some reasoner with RDF data, managed from TDB? Yes, see [1] > > Is it possible to manage an ontology in OWL2 from TDB? What means "manage"? In general you can load and query any RDF data into TDB. The serialization of an OWL ontology can be any RDF format. Obviously, querying OWL constructs via SPARQL can become weird because an OWL axiom/class expression can consists of more than one RDF triple.
[1] https://jena.apache.org/documentation/tdb/assembler.html -- Lorenz Bühmann AKSW group, University of Leipzig Group: http://aksw.org - semantic web research center