Wow, Graham, that was it -- brltty! "brltty accessibility service for blind people that is installed in Ubuntu and Ubuntu derivatives (Mint etc.) by default and have priority over serial devices plugged into the system later. Simply disable or remove this service."    I removed it, plugged in the cable, it connected, and stayed connected.  Opened CHIRP, connected to ttyUSB0 port, cloned my radio down.  Problem solved!

Thanks very much!

*________________________*

*Greg Beyer
[email protected]*


------------------------------------------------------------------------
*From:* Graham Whaley <[email protected]>
*Sent:* Monday, January 13, 2025 at 1:43 PM
*To:* CHIRP users list
*Cc:* Gregory Beyer
*Subject:* [users] Trouble with Linux USB port

It looks like there might be an app/service already running that might be 
causing the disconnect - see 
https://askubuntu.com/questions/1454633/dev-ttyusb0-device-connects-then-is-forced-to-disconnect-by-another-device

There are some hints on that page on how to disable that service afaict.

Graham

On 13 Jan 2025, at 18:32, Gregory Beyer via Users 
<[email protected]> wrote:

usbfs: interface 0 claimed by ch341 while 'brltty' sets config #1
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