I'm using spamassassin 2.64 on Debian Woody.
My clients emails are getting clobbered by "Pharma" spam. The messages seem to be using different encoding on words like Viagra, Cialis and sa is not picking them up.
Looks like a job for antidrug.cf:
http://mywebpages.comcast.net/mkettler/sa/antidrug.cf
(note: these rules are now built into SA 3.0 and higher, but I created them as an add-on before 3.0 came out and they work well with SA 2.64 )
Just download the file (I recommend downloading, copy-paste is too prone to error) and put it in /etc/mail/spamassassin alongside your local.cf. SA automatically parses *.cf in that directory so you don't need to add any options to enable it.
Run spamassassin --lint to make sure SA understands the new files and restart spamd (if you use spamd)