I've been running SA for about 2 months now, working really well (for the
most part) We do have a resources@ mailbox that I took a look at today and low and behold of the 2018 messages only 15 or so were legit, why would that
one account get hammered so much more than all others?

Could be any number of reasons. resources@ could be targeted by one of those viruses that send to specific defined addresses. Being a common word, and human resources is a common department in medium-sized and up companies, it's probably prone to dictionary attacks. The email address in question could be published on a website, newsletter archive, or usenet posting (just do a Google search for the address - it's a good bet that if it's in Google, then every spammer in the world has it).

If you're using Bayes, feed the spam and ham to it so that it knows what to look for for this user (though you'd need a lot more ham to make it effective, or for that matter for the Bayesian filtering to even be applied with the default 200 message threshold). Maybe set required_hits lower for this account, depending on how the legit messages scored. Depending on your mail setup, make sure that mail sent to resources@ on other domains on the box doesn't get funnelled into this one account.

But, you'll probably always be fighting an uphill battle to keep an already-tainted box clean. Better to just change the account name and/or email address and start from scratch, and make sure it stays clean.

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