Don't do this from spamassassin, reject messages sent to nonexistent users from your MTA (postfix, exim4, whatever you use). This will also lower the backscatter mail volume from your system (sending bounces to forged sender addresses).
Gabor Sipos > I was looking on the FAQ and the Wiki, but couldn't find this... > How do I filter based on the recipient mailbox address? For instance, I'm > running Linux, so if I get email sent to [EMAIL PROTECTED] or [EMAIL > PROTECTED] > then I know they're bogus... > And can probably block it, even if some of the recipients are valid email > addresses. > Thanks, > -Philip