other things to look for:

excessive collisions on the ethernet (unlikely)

Denial of Service attack in progress, look for lots of connections to the server that are doing "nothing"

what is the IP address/name of the MX in question?

what are your concurrencylocal and concurrencyremote settings in /var/qmail/control?

do you have any values set in timeoutremote and timeoutsmtpd?

just a few additional ideas off the top of my head

Paul Theodoropoulos
The Nicest Misanthrope on the Net

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