Not sure I am following your rationale - alteplase would have no effect on biofilm, just on fibrin and thrombosis.

Also the original message stated that the child has had positive cultures of yeast in the past. If the cultures through the current PICC are also yeast, antibiotics would not be effective. Has anyone had experience with using any of the anti-fungal drugs as a catheter locking solution? Lynn

At 1:36 PM -0600 11/29/05, Innes, Kim Bourn wrote:
I practice only in the pediatric area and we treat through the line, lock the line with the antibiotic and we also treat the line with alteplase two times a week. We do not start the alteplase until 3 - 4 days after starting antibiotics. There is not any research regarding the use of alteplase for line infection but our physicians feel that it helps because it gets rid of any biofilm inside the lumen that bacteria can latch on to easily.
Kim Innes, CRNI
University Healthcare
Columbia, MO

________________________________

From: [EMAIL PROTECTED] on behalf of Nicastro, Margaret
Sent: Tue 11/29/2005 12:03 PM
To: Stone, Gloria; Nancy Costa; Kimberly Sutters; [EMAIL PROTECTED]; [EMAIL PROTECTED]; Lynn Hadaway
Cc: Kimberly Sutters
Subject: RE: question for group new subject



Perhaps locking the line with an antibiotic that is sensitive to the bacteria would help. We have had great success when our nursing home patients come in with positive cultures from the port.

Margaret M Nicastro, CRNI, OCN
Coorordinator IV Therapy/Oncology
Gettysburg Hospital
147 Gettys Street
Gettysburg, PA 17325
Phone:  717-337-4312
Fax:  717-337-4485


________________________________

From: [EMAIL PROTECTED] on behalf of Stone, Gloria
Sent: Sun 11/27/2005 7:06 PM
To: Nancy Costa; Kimberly Sutters; [EMAIL PROTECTED]; [EMAIL PROTECTED]; Lynn Hadaway
Cc: Kimberly Sutters
Subject: RE: question for group new subject


Pediatric pt with short gut syndrome, often has positive blood cultures (yeast). Only way to take nutrition is venous. Has gone through multiple central lines in her short life (4 yrs old). Just had Picc placed per our radiologist on the 21st. Now Dr. wants to pull picc thinking it is cause of more + cultures even though she had + cultures when it was placed. Today he wanted me to pull Picc, then he decided to do culture from picc and perepheral. ANy ideas out there? Is there anything that can be placed in the Picc to deal with any contaminant that may have been caused by her + blood cultures?
We were never contacted about any of this until after the fact.
This poor child has really been through the mill. She was born with cancer. Not sure if i'm being very clear, but i'd sure like to save her getting the picc pulled and then getting a hickman, which will also be seeded soon too. Thanks, gloria stone Rogue Valley Medical Center

        -----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] Behalf Of Nancy Costa
        Sent: Monday, November 21, 2005 2:28 AM
To: Kimberly Sutters; [EMAIL PROTECTED]; [EMAIL PROTECTED]; Lynn Hadaway
        Cc: Kimberly Sutters
        Subject: Re: CT Contrast Extravasation
Recomendations for treatment of contrast media extravasations from the American College of Radiology are:
        Elevate affected extremity

        Apply ice packs at 15-60 minute intervals

        Call physician if volume > 5ml

        Consult plastic surgeon if volume:

                 > 30ml ionic contrast

                 > 100ml non-ionic contrast

        Monitor patient for:

                 Blistering

                 Ulceration

                 Altered tissue perfusion, sensation or temperature

                 Increased or persistent pain

American College of Radiology Committee on Drugs and Contrast Media. Manual on contrast media. 4th Ed. American College of Radiology, Reston, Va. 1998

        Hope this helps,

        Nancy Costa CRNI

                ----- Original Message -----
                From: Lynn Hadaway <mailto:[EMAIL PROTECTED]>
To: Kimberly Sutters <mailto:[EMAIL PROTECTED]> ; [EMAIL PROTECTED] ; [EMAIL PROTECTED]
                Cc: Kimberly Sutters <mailto:[EMAIL PROTECTED]>
                Sent: Saturday, November 19, 2005 1:01 PM
                Subject: Re: CT Contrast Extravasation

Immediate application of cold for anything that is hypertonic. Vitrase, a brand of hyaluronidase, is available now, but not aware of any published case reports. If severe, I would get a surgery consult as there could be compartment syndrome or necrotic ulcer depending on the volume and type of contrast. Lynn

                At 1:27 PM -0800 11/18/05, Kimberly Sutters wrote:

                        Content-Type: text/html
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                        Dear Colleagues -

Are you aware of specific treatment recommendations for the management of a contrast extravasation? We had a patient with an antecubital PIV who had a significant infiltration during administration of IV contrast with the power injector.

                        I would appreciate your feedback.

                        Thanks,

                        Kim

                        Kimberly A. Sutters, RN, PhD
Clinical Nurse Specialist, Surgical Services, Pain Management
                        Children's Hospital Central California
                        9300 Valley Children's Place (FW07)
                        Madera, CA 93638-8762
                        (559) 353-5440 (phone)
                        (559) 353-8049 (fax)
                        [EMAIL PROTECTED]
________________________________

                        Children's Hospital Central California
                        A Great Place to Get Better

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Lynn Hadaway, M.Ed., RNC, CRNI
                Lynn Hadaway Associates, Inc.
                126 Main Street, PO Box 10
                Milner, GA 30257
                http://www.hadawayassociates.com
                office 770-358-7861



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Lynn Hadaway, M.Ed., RNC, CRNI
Lynn Hadaway Associates, Inc.
126 Main Street, PO Box 10
Milner, GA 30257
http://www.hadawayassociates.com
office 770-358-7861


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