Ann,
Just some food for thought....
For the infusion you would use 2 mg/50 mls of diluent to infuse over 2 - 4 hours.
You would put 2 mg/2 mls in a clotted catheter.  Most catheters hold 1 mls or less.
So we are injecting tPa out the end of catheter every time we use Cathflo. 
Half life of tPa is 6 minutes from the time it comes in contact with the fibrin.
Since you would be infusing the 2 mg over 2 hours you would be infusing less
tPa over a period of time than if you injected the extra 1 mg out the end of the
catheter.  
 
The dose of 2 mg of Cathflo is 1/50th of the dose use for MI.   
I have not done home health in many years but I would be very comfortable with
doing this in the home.  We do infuse in an outpatient setting at least once a week.
 
Hope  this helps
Margy Galloway, RN
 
 
 
 


From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Ann Williams
Sent: Tuesday, March 21, 2006 1:20 PM
To: [EMAIL PROTECTED]
Subject: RE: Are you doing an instillation or an infusion of tpa? An infusion seems to work best for us for PWO.

We are doing the CathFlo in the home.......I'm sorry I wasn't clear...I was wondering if anyone is doing the infusion in the home...
 
Thanks!
 

Ann Williams RN CRNI
Infusion Specialist
Deaconess Home Services
600 Mary St.
Evansville, IN 47747
812-450-3828
812-450-4665 FAX

 


From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Blais, Gail
Sent: Tuesday, March 21, 2006 11:25 AM
To: Ward Gina; Monica Sorg; [EMAIL PROTECTED]
Subject: RE: Are you doing an instillation or an infusion of tpa? An infusion seems to work best for us for PWO.

We do this off and on for fibrin sheaths on ports, sometimes PICCs too. I can't remember the dose but it's pretty small, in 50ml of saline (both lumens if dual) over 3 hrs.
This is done in the renal unit quite often of hemo-lines that fibrin sheath and don't give adequate blood back .
So, intralumen if the problem is there and infusion if fluro has shown a fibrin sheath.  Gail
-----Original Message-----
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]On Behalf Of Ward Gina
Sent: Monday, March 20, 2006 4:05 PM
To: Monica Sorg; [EMAIL PROTECTED]
Subject: RE: Are you doing an instillation or an infusion of tpa? An infusion seems to work best for us for PWO.

I would like to hear more about the infusion of Activase.  ( is that what you are using?)  Is that use approved?  What would make you select that instead of instillation and sit?
 
Thanks in advance,
Gina Ward


From: [EMAIL PROTECTED] on behalf of Monica Sorg
Sent: Mon 3/20/2006 1:01 PM
To: [EMAIL PROTECTED]
Subject: Are you doing an instillation or an infusion of tpa? An infusion seems to work best for us for PWO.

Are you doing an instillation or an infusion of tpa?  An infusion seems to work best for us for PWO...2 mg in 50 ml saline infused over 3 hours.  Also, are you using a positive pressure cap?  That should help as well.  Is it being flushed often enough with enough saline.  We use 20 ml saline using the push pause method q 8 hrs.  Just a few ideas to consider.
 
 
 
Monica Sorg, RN CRNI
Infusion Nurse Specialist
University of Louisville Hospital
Louisville, KY
 
>>> "Ann Williams" <[EMAIL PROTECTED]> 3/20/2006 11:35 AM >>>

Hi folks!

We have a pt that has been requiring frequent declotting for PWO.  She was declotted successfully 2/20, 3/13 and now requiring it again.  She is being treated for an abscess in the spinal area and septicemia and has been on Vanco q12h since 2/10, and this past Friday (3/18) got switched to Merrem q8 and Zyvox q12.  She is 43yo and a compliant patient.  (YES there are some out there!!)  When we have PWO on one lumen, we Activase both lumens.  We flush with 10ml NaCl before and after each dose.

Does anyone have any suggestions for a pt requiring such frequent Activase?  Is there something we are overlooking?

Thanks!
ann

Ann Williams


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