Hi Vikram,
 we are actually looking into the issue of small vessels as part of our 
research with David.
It all depends on the point spread function of your acquisition system and how 
large is 
the vessel with respect to it.
What we are observing (that is already well known to the field) is that the 
usual gradient-based 
deformable models tend to underestimate the size of vessels on MR as they 
approach the size
of the acquisition resolution.
The workaround with vmtk is to use the -featureimagetype upwind option in 
vmtklevelsetsegmentation,
which tends to avoid severe underestimation of vessel size at the price of some 
overestimation.

Having said this, Daniel is right, you really need a ground truth, and if you 
have a mouse scanner
at your disposal the best is to build a simple phantom and scan it at different 
resolutions. This
way you will be sure that you are tuning the segmentation method to your 
specific acquisition
modality. Even talking about MR may not make sense in itself: you need to know 
what sequence
you are using, since, e.g. phase contrast vs contrast-enhanced vs k-centric 
contrast-enhanced
sequences may lead to different signals for the same shape.

If you do anything like this it would be great if you let me know about it, as 
we are very interested 
in these kinds of issues.

Best regards


Luca



On Feb 8, 2011, at 6:39 PM, Daniel Haehn wrote:

> Hi Vikram,
> 
> I did something similar during my Master's thesis. You can find it here
> http://www.spl.harvard.edu/publications/item/view/1957
> 
> You need an expert segmentation as a ground truth and a comparison metric to 
> do so.
> 
> Cheers,
> Daniel
> 
> On Jan 31, 2011, at 6:43 AM, Vikram Mehta wrote:
> 
>> Hello,
>> 
>> I am learning to use vmtk to segment and extract carotid arteries from 
>> MRI/CT data of mice. 
>> I am managing to get the surface model but as you know, the diameters of 
>> mouse arteries are really small and I would like to know if the model that 
>> VMTK produces is accurate in terms of diameter and other dimensions ? 
>> 
>> Is there a way to measure the error (if any) in the diameter of the model 
>> with respect to the original ?
>> 
>> Thank you in advance
>> Vikram.
>> 
>> 
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