2015-01-28 7:45 GMT-07:00 Daniel Allen <[email protected]>:
> Hello,
>
> I am trying to perform IBI on a bilayer formed of some polymers. I have
> obtained distributions for non-bonded and bonded interactions from csg_stat
> and feed these into csg_inverse in *dist.tgt files. I am not currently
> iterating bonded interactions, just using csg_inverse to produce tabulated
> potentials (bonds, angles, dihedrals).
>
> My RDFs do not quite converge to 1 as my reference system is not homogeneous
> so I am cutting off interactions at the first minimum in the RDFs (at
> approximately 0.75 nm).
>
> After about 10 integration steps in the first iteration, the simulation
> blows up. The initial configuration is the last snapshot of my atomistic
> reference simulation mapped onto CG representation.
>
> I have looked at the nb potentials (they seem reasonable) and have run a
> script to determine the shortest distance between 2 non-bonded beads in my
> initial conf.gro that I feed in as the starting state. The shortest distance
> is 0.328 nm and sigma for that pairwise interaction is 0.41 nm. This would
> result in an interaction energy of ~12.8 kJ/mol which doesn't seem
> ridiculously high?
>
> Any ideas how to move past this? I could try using a different starting
> state but I fear that any snapshots from the reference system will have pair
> distances < sigma.
It is really hard to say how to overcome this, but I have more general
list of advice:
1.) Scale the update
2.) Change the update sequence if you have multiple interactions
3.) Use last configuration from the previous step ("laststep") as
initial configuration
4.) Do a pre simulation in each iteration step (pre_simulation) to
minimize the initial configuration
5.) Increase the min to only update parts of the potential
6.) Longer coarse-grained simulations
7.) Apply a transformation on the rdf before doing the update
8.) Use an initial guess (pot.in) on a bigger interval with premolded structure

Christoph

>
>
> Thanks in advance,
>
> Dan.
>
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-- 
Christoph Junghans
Web: http://www.compphys.de

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