I looked at simplex tutorials. I don,t now why we need n+1 line, furthermore, 
when i tried to run my settings.xml based on the a combination rule I got the 
error mentioning there is no parameters for interaction between two beads. I am 
trying simplex on a four bead model so I don't have enough parameters to 
allocate for all of the interaction.

> On Apr 9, 2016, at 2:49 PM, Christoph Junghans <[email protected]> wrote:
> 
> 2016-04-08 22:26 GMT-06:00 Alireza Moradzadeh <[email protected]>:
>> By the way I would be glad if you could provide more information on how to
>> choose parameters initials
>> I could not find so much information on how I should choose those value or
>> even its organization
> Have a look at the methanol-water simplex tutorial there is a
> simplex.in file for each interaction.
> The values in there are given in the same order as in the xml file.
> You will need n+1 sets to start with (lines in simplex.in) These sets
> can be generated by randomly perturbing some values from a single set,
> which you got from e.g. fitting an IBI potential.
> 
> Christoph
> 
>> 
>> Thanks,
>> Alireza
>> 
>> 
>>> On Friday, April 8, 2016 at 10:21:23 PM UTC-5, Alireza Moradzadeh wrote:
>>> 
>>> Thank you for your answer.
>>> 
>>> I am also wondering if there is a way to keep eps and sigma positive
>>> during simulation time. Because the optimization method is blind to physical
>>> meaning of eps and sigma I got negative value using other methods in votca
>>> package.
>>> Is it possible to enforce this condition using this method or RE. Also is
>>> there anyway in votca package to treat charge of beads as a variable during
>>> simulation so I could control sigma and epsilon by variable charge.
>>> 
>>> Thanks,
>>> Alireza
>>> 
>>> 
>>>> On Friday, April 8, 2016 at 4:04:48 PM UTC-5, Christoph Junghans wrote:
>>>> 
>>>> 2016-04-07 19:10 GMT-06:00 Alireza Moradzadeh <[email protected]>:
>>>>> Dear VOTCA Users,
>>>>> 
>>>>> 
>>>>> For a system composed of two beads , I want to optimize pressure and
>>>>> interaction based on RDF but I want to stick to Lorentz-Berthelot
>>>>> combination rule. I want to know if I define my function as follows
>>>>> would it
>>>>> be right or not? and should I define pressure as target in each
>>>>> interaction.
>>>> Parameters are always global so, you should not list any parameter
>>>> twice, but you need to list at least one parameter for each
>>>> interaction.
>>>> e.g. list eps1 sig1 for CG1-CG1, eps2 for CG1-CG2 and sig2 for CG2-CG2
>>>>> 
>>>>> CG1-CG1
>>>>> target rdf presssure
>>>>> function  4*eps1*[(sig1/x)**12-(sig1/x)**6]
>>>>> parmeters eps1 sig1
>>>>> 
>>>>> CG1-CG2
>>>>> target rdf pressure
>>>>> function 4*(eps1*eps2)**2*[((sig1+sig2)/2/x)**12-(sig1+sig2)/2/x)**6]
>>>> This should be square root and not Power 2.
>>>> 
>>>> Christoph
>>>>> parameters eps1 sig1 eps2 sig2
>>>>> 
>>>>> 
>>>>> CG2-CG2
>>>>> target rdf presssure
>>>>> function  4*eps2*[(sig2/x)**12-(sig2/x)**6]
>>>>> parmeters eps2 sig2
>>>>> 
>>>>> Thanks,
>>>>> 
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>>>> 
>>>> 
>>>> 
>>>> --
>>>> Christoph Junghans
>>>> Web: http://www.compphys.de
>> 
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> 
> 
> 
> -- 
> Christoph Junghans
> Web: http://www.compphys.de
> 
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