I am actually researching the same problem. Please take a look here:

https://groups.google.com/d/topic/modwsgi/DW-SlIb07rE/discussion
http://bugs.python.org/issue13156

This is a bug in python 2.7.2, and has been solved in 2.7.3. I am also 
affected, and will have to upgrade all my servers :(

On Tuesday, January 15, 2013 11:51:44 AM UTC+1, Niphlod wrote:
>
> I may be out of line here, but the problem may lie in the fact that if you 
> want to start a subprocess usually subprocess.call uses a thread to 
> communicate with it..... uwsgi doesn't allow to spawn your own threads as 
> long as you don't supply the --enable-threads parameter.
>
> PS: spawning processes from a web-app poses always a lot of problems 
> (concurrency, pipes, stderrs, inherited socket, and so on). Be sure of what 
> you're doing.
>
> Il giorno martedì 15 gennaio 2013 06:30:14 UTC+1, Richard Penman ha 
> scritto:
>>
>> hello,
>>
>> I set up a uwsgi / nginx server using 
>> the setup-web2py-nginx-uwsgi-ubuntu.sh script.
>> However I find when the app tries to start a sub-process I get this error:
>>
>> Fatal Python error: Couldn't create autoTLSkey mapping
>>
>> I read around and apparently this can happen when lack of memory.
>>
>> Do you see any problems with these uwsgi settings:
>> <uwsgi>
>>     <socket>/tmp/web2py.socket</socket>
>>     <pythonpath>/var/www/web2py/</pythonpath>
>>     <mount>/=wsgihandler:application</mount>
>>     <master/>
>>     <processes>4</processes>
>>     <harakiri>60</harakiri>
>>     <reload-mercy>8</reload-mercy>
>>     <cpu-affinity>1</cpu-affinity>
>>     <stats>/tmp/stats.socket</stats>
>>     <max-requests>2000</max-requests>
>>     <limit-as>512</limit-as>
>>     <reload-on-as>256</reload-on-as>
>>     <reload-on-rss>192</reload-on-rss>
>>     <uid>www-data</uid>
>>     <gid>www-data</gid>
>>     <cron>0 0 -1 -1 -1 python /var/www/web2py/web2py.py -Q -S welcome -M 
>> -R scripts/sessions2trash.py -A -o</cron>
>>     <no-orphans/>
>> </uwsgi>
>>
>

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