Hello Leonel, thank you for your reply. Then how could I find the reason 
for the failure? 
I tried the way you suggested in this page:
https://groups.google.com/forum/#!searchin/web2py/mail.settings.hostname/web2py/pZT38v_s5OI/9Og3cQefLkkJ.
 

However, the code "server = smtplib.SMTP('mydomain', 25)" returns the same 
error "error: [Errno 13] Permission denied".
I also tried this in python command line on the server with the same 
setting, which works fine. 


On Tuesday, November 11, 2014 5:44:22 PM UTC+1, Leonel Câmara wrote:
>
> That's not due to apache settings, that's due to the way you configured 
> web2py mail settings or your mail server configuration. Permission denied 
> can be caused because you didn't set mail.settings.login correctly, it can 
> be because you didn't set mail.settings.hostname to a hostname your mail 
> server is configured to allow, etc. It can be for many different reasons.
>

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