> prototype - suggest you start by establishing the basic data you want;
> You can create the table definitions in the admin interface, and then 
> load them with some test data from csv files in the admin interface.
Actually, you don't need to create tables.
Because you seem to upload different data everytime for new calculations.
Would that mean that you create a new table in the database everytime?
I doubt that you want this.

Do you care for storing the input in web2py?

If not,
1) just read serve your data as a stream to a StrinIO.
Massimo may tell more about this.

2) read the stream with numpy into an array:
Example: 
http://www.nabble.com/numpy:-loadtxt-with-default-value-td24987747.html

3) then use array for your number crunching.

You may find some inspriation her:
http://books.google.de/books?id=j7QbD83-h8AC&lpg=PP1&pg=RA2-PA275
Its use of cgi may be outdated. But there are some good ideas for the 
design.

Please keep us updated or even post your app,
Timmie


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