The syntax for url with domains is a bit more complex than what you've tried. It's "[remote address]:[protocol]://[host]:[method] [path]".
To make the following rewriting: http://domain1.com/ -> http://domain1.com/d1/default/index http://domain2.com/ctr/fcn -> http://domain2.com/d2/ctr/fcn http://domain3.com/ctr/fcn/arg1/arg2 -> http://domain3.com/d3/ctr/fcn/arg1/arg2 use these rules for routes_in: (".*http://domain1.com.* /", "/d1/default/index"), (".*http://domain2.com.* /", "/d2/default/index"), (".*http://domain3.com.* /", "/d3/default/index"), (".*http://domain1.com.* (.*)", r"/d1\1"), (".*http://domain2.com.* (.*)", r"/d2\1"), (".*http://domain3.com.* (.*)", r"/d3\1") To also get the URL created paths rewriting, for example: http://domain1.com/d1/defualt/index -> / http://domain1.com/d1/ctr/fcn -> /ctr/fcn use these rules for routes_out: ("/(d1|d2|d3)/defualt/index", "/"), ("/(d1|d2|d3)(.*)", r"\2")
