Wireguard and double NAT

[Hendrik Friedel]

Hello,

I have a running Server serving several Clients with a wireguard tunnel 
already. For this, port 51820 UDP is porwarded in my router to the 
Server.

Now, I have one Client with a bit of a tricky setup: I have two Routers 
doing NAT. For one of those, I have no control, i.e. I cannot setup 
portforwarding.

Is it still possible, to use Wireguard to create a tunnel between my 
server and this tricky client? If so, is there anything special, that I 
need to consider?

Best regards,
Hendrik