I am also hitting the same issue. As soon as my build process starts .. it
pop-up me this message "This program cann't start because mspdb100.dll is
missing from your computer. Try reinstalling the program to fix this
problem"

I am using Microsoft Visual studio 10.0. I have mspdb100.dll present in
common7/IDE folder.I contain latest changeset 77(6520d4d1498f)


Following is build result



NAnt 0.91 (Build 0.91.4312.0; release; 10/22/2011)
Copyright (C) 2001-2011 Gerry Shaw
http://nant.sourceforge.net

Buildfile: file:///d:/Wix/wix.build
Target framework: Microsoft .NET Framework 4.0
Target(s) specified: inc 

 [property] Target framework changed to "Microsoft .NET Framework 2.0".
 [property] Read-only property "dir.hhw" cannot be overwritten.
 [property] Read-only property "hhw-found" cannot be overwritten.
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Microsoft\VisualStudio\10.0\Setup\VS\Pro\';hive='LocalMachine';
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Microsoft\VisualStudio\10.0\Setup\VS\VSTA\';hive='LocalMachine';
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Microsoft\VisualStudio\10.0\Setup\VS\VSTD\';hive='LocalMachine';
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Microsoft\VisualStudio\10.0\Setup\VS\VSTT\';hive='LocalMachine';
     [echo] Pre-requisite Check Passed: Visual Studio 10.0 Test Tools are
installed.
     [echo] Pre-requisite Check Passed: .Net Framework 4.0 Full is
installed.
     [echo] Pre-requisite Check Failed: Microsoft.Web.Administration.dll is
not installed.
     [echo] Pre-requisite Check Failed: Qtests directory was not found.

global.initTools:

[readregistry] Registry Path Not Found! -
key='SOFTWARE\Microsoft\VisualStudio\8.0\Setup\VC\';hive='LocalMachine';
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Wow6432Node\Microsoft\VisualStudio\8.0\Setup\VC\';hive='LocalMachine';
     [echo] Couldn't find the Visual Studio 2005 VC Directory.
VS2005-compatible versions of libraries will be excluded from the build.
     [echo] Found Visual Studio 2010 VC Directory : C:\Program
Files\Microsoft Visual Studio 10.0\VC\
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Microsoft\VisualStudio\9.0\Setup\VC\';hive='LocalMachine';
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Wow6432Node\Microsoft\VisualStudio\9.0\Setup\VC\';hive='LocalMachine';
     [echo] Couldn't find the Visual Studio 2008 VC Directory.
VS2008-compatible versions of libraries will be excluded from the build.
     [echo] Setting main VC directory to : C:\Program Files\Microsoft Visual
Studio 10.0\VC\
[readregistry] Registry Path Not Found! - key='SOFTWARE\Microsoft\Microsoft
SDKs\Windows\v7.1\';hive='LocalMachine';
[readregistry] Registry Path Not Found! -
key='SOFTWARE\Wow6432Node\Microsoft\Microsoft
SDKs\Windows\v7.1\';hive='LocalMachine';
     [echo] Setting PlatformSDKDir directory to : C:\Program Files\Microsoft
SDKs\Windows\v7.0A\
     [echo] Setting SQLCEDir directory to : C:\Program Files\Microsoft SQL
Server Compact Edition\v3.5\

setPlatform:

     [echo] Setting architecture to x86 with VC tools version 10

prereqcheck:


snskip:

   [delete] Deleting file C:\Users\sgupta\AppData\Local\Temp\tmpB137.tmp.

initbuildenv:


makeDirs:


appsynup.inc:


makeNativeLib:


checkRequiredArgs:


compileCpp:


checkRequiredArgs:

       [cl] Compiling 1 files to 'd:\Wix\build\obj\debug\x86\ambient'.

BUILD FAILED - 10 non-fatal error(s), 2 warning(s)

External Program Failed: cl (return code was -1073741515)

Total time: 3.1 seconds.


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