Lisa CO2000 <[email protected]> wrote

Why isn't OUR media covering this, given there is a Baxter lab in Illinois?

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Baxter: Product contained live bird flu virus
By Helen Branswell, THE CANADIAN PRESS

Last Updated: 27th February 2009, 3:26pm

The
company that released contaminated flu virus material from a plant in
Austria confirmed Friday that the experimental product contained live
H5N1 avian flu viruses. 

And an official of the World Health
Organization’s European operation said the body is closely monitoring
the investigation into the events that took place at Baxter
International’s research facility in Orth-Donau, Austria. 

“At
this juncture we are confident in saying that public health and
occupational risk is minimal at present,” medical officer Roberta
Andraghetti said from Copenhagen, Denmark. 

“But what remains unanswered are the circumstances surrounding the incident in 
the Baxter facility in Orth-Donau.” 

The
contaminated product, a mix of H3N2 seasonal flu viruses and unlabelled
H5N1 viruses, was supplied to an Austrian research company. The
Austrian firm, Avir Green Hills Biotechnology, then sent portions of it
to sub-contractors in the Czech Republic, Slovenia and Germany. 

The
contamination incident, which is being investigated by the four
European countries, came to light when the subcontractor in the Czech
Republic inoculated ferrets with the product and they died. Ferrets
shouldn’t die from exposure to human H3N2 flu viruses. 

Public
health authorities concerned about what has been described as a
“serious error” on Baxter’s part have assumed the death of the ferrets
meant the H5N1 virus in the product was live. But the company, Baxter
International Inc., has been parsimonious about the amount of
information it has released about the event. 

On Friday, the company’s director of global bioscience communications confirmed 
what scientists have suspected. 

“It was live,” Christopher Bona said in an email. 

The
contaminated product, which Baxter calls “experimental virus material,”
was made at the Orth-Donau research facility. Baxter makes its flu
vaccine — including a human H5N1 vaccine for which a licence is
expected shortly — at a facility in the Czech Republic. 

People
familiar with biosecurity rules are dismayed by evidence that human
H3N2 and avian H5N1 viruses somehow co-mingled in the Orth-Donau
facility. That is a dangerous practice that should not be allowed to
happen, a number of experts insisted. 

Accidental release of a mixture of live H5N1 and H3N2 viruses could have 
resulted in dire consequences. 

While
H5N1 doesn’t easily infect people, H3N2 viruses do. If someone exposed
to a mixture of the two had been simultaneously infected with both
strains, he or she could have served as an incubator for a hybrid virus
able to transmit easily to and among people. 

That mixing process, called reassortment, is one of two ways pandemic viruses 
are created. 

There is no suggestion that happened because of this accident, however. 

“We have no evidence of any reassortment, that any reassortment may have 
occurred,” said Andraghetti. 

“And
we have no evidence of any increased transmissibility of the viruses
that were involved in the experiment with the ferrets in the Czech
Republic.” 

Baxter hasn’t shed much light — at least not
publicly — on how the accident happened. Earlier this week Bona called
the mistake the result of a combination of “just the process itself,
(and) technical and human error in this procedure.” 

He said he
couldn’t reveal more information because it would give away proprietary
information about Baxter’s production process. 

Andraghetti
said Friday the four investigating governments are co-operating closely
with the WHO and the European Centre for Disease Control in Stockholm,
Sweden. 

“We are in very close contact with Austrian
authorities to understand what the circumstances of the incident in
their laboratory were,” she said. 

“And the reason for us
wishing to know what has happened is to prevent similar events in the
future and to share lessons that can be learned from this event with
others to prevent similar events. ... This is very important.” 


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