When I was working with GTK2 I started out by hand writing the windows. Then I learned about Glade which made life a lot easier. Then, after a while I felt that I always have to hand adjust things and stopped using Glade.
In wx I have not used any of the gui generators. In Padre, the Perl IDE ( http://padre.perlide.org/ ) we hand-write everything. I guess other can use these GUI creator tools better than I can which is not that surprising as I have been using mostly command line tools for many years and have not written many GUI applications. So while I am not really a GUI person I'd really like to see some capabilities in Padre to create simple desktop applications using wxWidgets. So if during your learning period you'd like to play with such a tool you are more than welcome! regards Gabor
