\documentclass{article}
\usepackage{polyglossia}
\setmainfont{Charis SIL}
\newfontfamily\sanskritfont[Script=Devanagari]{Sanskrit 2003}
\begin{document}
Here's some text in the default font,
Charis, and {\sanskritfont
अत्र देवनागरीलिप्युदाहरणम् वर्तते| \par}
\end{document}
output:
[image: pic_005.png]
<<pic_005.png>>
-------------------------------------------------- Subscriptions, Archive, and List information, etc.: http://tug.org/mailman/listinfo/xetex
