Hello Krishna--

> Please find the attached wrefine.py script and the PDB-extract file for
> coordinates.
> 
> The file containing valiation issues (copied from PDB deposition website) is 
> also
> included here.
> 

I see that the validation report isn't particularly clear. However, if
you run the torsionReport helper program(*), you'll see that the omega
angles contain significant deviations from 180 degrees. Looking at the
wrefine script, I see that you are not using Xplor-NIH
waterRefineTools.refine function, but rather some function that was
added to your local version of Xplor-NIH, so I can't help too much more
unless you modify your script to use our tools. I believe you should
get good results with either eginput/gb1_rdc/refine_eefx.py or
eginput/gb1_rdc/wrefine.py from Xplor-NIH version 2.45.

best regards--
Charles

* torsionReport will not work with the mmCIF file you sent me- a fix
  is required, and will be available in the Xplor-NIH
  release. However, torsionReport should work fine with the PDB files
  output from the Xplor-NIH scripts.
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