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Hello Edward--

> 
> I am using refine.py to refine a structure in Xplor-NIH and submitted
> the top 20 structures to the PSVS server for validation.  The models
> came back with a high MolProbity clash score (~51) indicating VDW
> clashes.
> 

I have heard of other reports of bad molprobity scores for structures
which Xplor-NIH thinks are fine. Perhaps some of the atom radii need
updating. If I can get some information about which atoms are clashing,
I might be able to fix this.


> 
> Powell::step: irregular exit: Line search abandoned: gradient may be
> incorrect 

These messages are normal, and should not be of concern unless only a
very small number of steps are being taken.

best regards--
Charles
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