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Hello Misbah--

> 
> I was wondering whether anyone has had the problem of generating  
> structures using an annealed script which give LOWER RMSD values than  
> the structures generated using a refinement script?
> 
> For my large molecules I have always obtained lower RMSDs in the  
> refined structures. HOwever I am not sure why this isnt the case for  
> my smaller molecule? Any ideas would be very helpful.
> 

which annealing and refinement protocols are you using? This sort of
behavior depends very much on the details of the scripts. Are your
annealed structures acceptable?

best regards--
Charles
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