Respected fellow members I am trying to use XPLOR module to perform Molecular dynamics simulated annealing of a symmetric trimer along with NOE restrains. I am not well versed with the usage of the programme and was following a journal article *"Unraveling the symmetry ambiguity in a hexamer: Calculation of the R6 human insulin structure*" and a book chapter "*Calculation of Symmetric Oligomer Structures from NMR Data"* published by O’Donoghue et. al. I was hoping that the usage of the MDSASO-WDMR protocol by professor O’Donoghue, would be suitable for my calculations. However, somehow I am not being able to avail it from: O’Donoghue, S.I. (1998) Protocols for symmetric oligomers. *http://www.EMBLHeidelberg.DE/nmr/nilges/NMRProtocols/SymmetricOligomers.html <http://www.EMBLHeidelberg.DE/nmr/nilges/NMRProtocols/SymmetricOligomers.html>* as the paper suggests. It would be very helpful if someone having any information on this matter can guide me.
Thank You with regards Rajbinder Kaur Virk -- *With regards* *Rajbinder Kaur Virk* *Research Scholar * *Department of Biophysics* *Panjab University * *Chandigarh-160014*
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