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Fountain of Youth: Drug Restores Muscles
By LiveScience Staff
posted: 04 November 2008 05:33 pm ET
A daily dose of an investigational medication has been found to restore muscle
mass in the arms and legs of older adults and improve some of their
biochemistry to levels found in healthy young adults, suggesting an
anti-frailty drug has been found.
The drug, called MK-677, was evaluated for its safety and effectiveness in a
study that showed the drug restored 20 percent of muscle mass loss associated
with normal aging. In fact, levels of growth hormone (GH) and of insulin-like
growth factor I (IGF- I) in healthy seniors who took the drug increased to the
levels found in healthy young adults, said Michael O. Thorner, a professor of
internal medicine and neurosurgery at the University of Virginia Health System.
"Our study opens the door to the possibility of developing treatments that
avert the frailty of aging," Thorner said. "The search for anti-frailty
medications has become increasingly important because the average American is
expected to live into his or her 80s, and most seniors want to stay strong
enough to remain independent as they age."
Funded by the National Institutes of Health, the two-year, double-blind,
placebo-controlled study involved 65 men and women ranging in age from 60 to
81. The results are detailed in the Nov. 4, 2008, issue of the journal Annals
of Internal Medicine.
The drug mimics the action of ghrelin, a peptide that stimulates a growth
hormone called secretagogue receptor (GHSR). Drug developers are focusing on
GHSR because it plays an important role in the regulation of growth hormone and
appetite. They think it may prove to be an excellent treatment target for
metabolic disorders such as those related to body weight and body composition.
Drugs found to work in early trials don't always hold up to further testing,
The new research was a "proof-of-concept" study that sets the stage for a
larger and longer clinical trial to determine whether MK-677 is effective in
people who are frail and to assess its long-term safety.
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