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Researchers learn that some 'good cholesterol' isn't good enough
Published: Monday, December 1, 2008 - 00:56 in Health & Medicine
Learn more about: cholesterol hdl cholesterol ldl faseb journal gerald
weissmann good cholesterol lipid chemistry
If you think your levels of "good cholesterol" are good enough, a new study
published in the December 2008 issue of The FASEB Journal suggests that you may
want to think again. In the report, researchers from the University of Chicago
challenge the conventional wisdom that simply having high levels of good
cholesterol (HDL) and low levels of bad cholesterol (LDL) is necessary for good
heath. Instead, they show that the good cholesterol has varying degrees of
quality and that poor quality HDL is actually bad for you. "For many years, HDL
has been viewed as good cholesterol and has generated a false perception that
the more HDL in the blood, the better," said Angelo Scanu, M.D., a pioneer in
blood lipid chemistry from University of Chicago and first author of the study.
"It is now apparent that subjects with high HDL are not necessarily protected
from heart problems and should ask their doctor to find out whether their HDL
is good or bad."
The researchers came to this conclusion after reviewing published research on
this subject. In their review, they found that the HDL from people with chronic
diseases such as rheumatoid arthritis, kidney disease, and diabetes is
different from the HDL in healthy individuals, even when blood levels of HDL
are comparable. They observed that normal, "good," HDL reduces inflammation,
while the dysfunctional, "bad," HDL does not.
"This is yet one more line of research that explains why some people can have
perfect cholesterol levels, but still develop cardiovascular disease," said
Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "Just as the
discovery of good and bad cholesterol rewrote the book on cholesterol
management, the realization that some of the 'good cholesterol' is actually bad
will do the same."
Source: Federation of American Societies for Experimental Biology
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