At 09:29 PM 11/16/02, Stephen Beecroft wrote:
-Ronn- >> (FWIW, I've been unable to find out why there is apparently no >> such compound as 1,7-trimethylxanthine. > > Oops. I meant 1,7-dimethylxanthine . . .Also called "paraxanthine"; described as an adenosine receptor ligand and a major metabolite of caffeine at http://www.sigma-aldrich.com/rbi/datasheet/a005dat.pdf
Do tell. I wonder why this page never turned up before? I know there's a dead tree version of the Sigma-Aldrich catalog in the department office: I will have to look in there. I suppose that it's possible that the only listing in Merck or the CRC is under "paraxanthine" without any other cross-reference . . .
Sigma-RBI brand products are sold through Sigma-Aldrich, Inc.
Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply.
Please see reverse side of the invoice or packing slip.
Cat. No. A-005
Adenosine receptor ligand; major metabolite of caffeine.
Mol. Formula: C7 H8 N4 O2
Mol. Wt.: 180.17 (anhyd.)
CAS Registry No.: 611-59-6
Chemical Name: 3,7-Dihydro-1,7-dimethyl-1H-purine-2,6-dione
Physical Properties: White solid.
Caution: Due care should be exercised to prevent skin contact, ingestion or inhalation of this compound.
RTECS No. RV9380000.
Pharmacology: Ki = 30 mM at A1 receptors.
Storage: Store tightly sealed at room temperature.
Solubility: Soluble in 0.1N NaOH (2 mg/ml), water (1 mg/ml) or ethanol (0.6 mg/ml).
Disposal: Dissolve or mix the compound with a combustible solvent and burn in a chemical incinerator
equipped with an afterburner and scrubber.
[Sounds like fun stuff . . . ]
1. Snyder, S.H., Katims, J.J., Annau, Z., Bruns, R.F., Daly, J.W. "Adenosine receptors and behavioral actions of methylxanthines." Proc. Natl. Acad. Sci. USA 78, 3260 (1981).
2. Ferre, S., Guix, T., Salles, J., Badia, A., Parra, P., Jane, F., Herrera-Marschitz, M., Ungerstedt, U., Casas, M. "Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes." Eur. J. Pharmacol. 179, 295-299 (1990).
I always knew that I would see the first man on the Moon.
I never dreamed that I would see the last.
--Dr. Jerry Pournelle
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