I am just starting to try-out Dojo (http://dojotoolkit.org).
Interestingly, the RPC it does is JSON-RPC. Since I am well-acquainted
with JSON-RPC support in Zope 3, I have put together a package for
making Dojo and its JSON-RPC client work with Zope 3.
At the moment, Dojo is just a new toy for me, but I see a lot of
potential for rich user interfaces using Zope 3 and Dojo.
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