Mayo Clinic Collaborative Research Building Opens on Scottsdale 
Campus

Collaboration with TGen brings hope for cancer cures

06-29-2005

SCOTTSDALE, Ariz. -- A major milestone in the advancement of cancer 
research for residents of Arizona and beyond will be realized later 
this week with the dedication of a new biomedical scientific 
facility that joins Mayo Clinic and the Translational Genomics 
Research Institute (TGen) in a unique strategic partnership. The 
partners' combined technological, academic, research and clinical 
expertise will help bring innovative research findings directly to 
the bedside of patients. 
The physical manifestation of this ambitious research collaboration 
is the new Mayo Clinic Collaborative Research Building (MCCRB), a 
110,000 square-foot facility that will officially open on Thursday, 
June 30, on the Scottsdale campus of Mayo Clinic. The $25 million 
facility was funded by Scottsdale developer Tom Hornaday of Hornaday 
Development. The building is the first of its kind for Mayo Clinic 
in that it brings multiple strategic partners under one roof 
dedicated to scientific discovery and therapeutics to ease the 
burden of disease for the people of Arizona and around the world. 

Ground was broken in February 2004 for the MCCRB, which is located 
south of the main clinic facility and directly north of the S.C. 
Johnson Research Building. The collaboration represents a broadening 
of the scope of research between the Mayo Clinic and TGen extending 
beyond it's initial focus on melanoma. Tenants of the building thus 
far include: 

Mayo Clinic research business offices 
Mayo Clinic researchers, including investigational labs for 
hematologic malignancies, multiple myeloma and pancreatic cancer 
TGen's Cancer Drug Development Laboratory (CDDL) and the TGen 
subsidiary, TGen Drug Development (TD2) 
Jeffrey M. Trent, Ph.D., is president and scientific director of 
TGen. Dr. Daniel Von Hoff, TGen executive vice president, is also 
director for TGen's Translational Research Division and the director 
of TD2. In addition to leading TGen's clinical enterprise, Von 
Hoff's team is involved in translating basic genetic, molecular and 
biochemical observations to create therapies for patients with 
pancreatic cancer. 

The CDDL provides a centralized set of resources for investigators 
interested in the recent explosion in molecular medicine and 
genomics-based diagnostics and treatment methods. The combination of 
world-class researchers and the latest technologies create a highly 
collaborative multidisciplinary research environment. The goal is to 
develop innovative preclinical research products based on an 
individual's disease and associated molecular profiles that are 
brought to bear on cancer as quickly as possible. 

Mayo Clinic, headed by Dr. Victor F. Trastek, chair of the Board of 
Governors, has research investigators who work closely with 
clinicians to translate discoveries into therapies for patients. 
Specifically, their work supports the Mayo Clinic Cancer Center, one 
of only 38 U.S. medical centers named a National Cancer Institute 
(NCI)-designated Comprehensive Cancer Center. Mayo's clinical and 
research experts join forces to address the complex needs of 
oncology patients. 

The principal collaborative partners who will be housed at the MCCRB 
partners share a passion for cooperation among institutions and 
individuals to bring advances to cancer research. But they also 
share something more -- compelling personal stories reflective of 
their commitment to cancer research. 

Developer Hornaday and his wife, Ruth Ann, lost their daughter, 
Kristi, 26, to melanoma. Hornaday's mother died at age 52 of breast 
cancer. "My hope, my prayer and my belief is that the research 
conducted in this building will result in cures so others will not 
experience these kinds of untimely losses," notes Hornaday. 

Speakers at the opening will include Trastek, Trent, Von Hoff and 
Hornaday, as well as Scottsdale Mayor Mary Manross and Dr. Laurence 
Miller, deputy director of the Mayo Clinic Cancer Center. Both Trent 
and Von Hoff share Hornaday's passion for finding a cure. They 
experienced the loss of a close friend and mentor when founding 
Arizona Cancer Center director, Dr. Sydney Salmon, passed away in 
2002. 

Trastek is a thoracic surgeon who has witnessed more than his share 
of cancer-related diseases. At one time in his practice he chaired a 
committee of the Society of Thoracic Surgeons whose charge was a 
high-profile public campaign to encourage smoking cessation. 

"Pursuing joint research strategies and building strong partnerships 
with researchers at TGen helps advance Mayo Clinic's mission of 
integrating research and education with clinical medicine to provide 
optimal health care for our patients and patients everywhere," said 
Trastek. 

"The TGen-Mayo Clinic collaboration signifies a milestone, both in 
terms of Arizona's leadership in bringing the best that biomedicine 
has to offer to patients nationally and internationally and the 
potential that research results between these two institutions will 
have toward defeating cancer," said Sen. John McCain. 

For Trent, it's the extension of a research vision that began with 
TGen's formation in 2002. 

"The collaboration signifies hope for those patients battling 
cancer. All of us in this partnership understand their urgency, and 
together we are committed to moving swiftly toward solutions that 
will make a difference in our patients lives," said Trent. 

About Mayo Clinic
Mayo Clinic is a charitable, not-for-profit organization with 
locations in Arizona, Minnesota and Florida. For more than a 
century, Mayo has been an international leader in patient care, 
health sciences research and medical education. Since opening in 
Scottsdale in 1987, Mayo has evolved into an integrated, multi-
campus system that includes the clinic, the Samuel C. Johnson 
Research Building and the Mayo Clinic Collaborative Research Center 
in Scottsdale, and Mayo Clinic Hospital in northeast Phoenix. 

About TGen
The mission of the Translational Genomics Research Institute (TGen) 
is to make and translate genomic discoveries into advances in human 
health. Translational genomics research is a relatively new field 
employing innovative advances arising from the Human Genome Project 
and applying them to the development of diagnostics, prognostics and 
therapies for cancer, neurological disorders, diabetes and other 
complex diseases. TGen is focused on personalized medicine and plans 
to accomplish its goals through robust and disease-focused research 
programs and its state-of-the-art bioinformatics and computational 
biology facilities. 



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