PISA gives a good analysis of a known interface, but won't predict it from scratch. So basically you need a protein-protein docking program of which there are several:
3DDock, gramm, zdock, etc, etc There's a review in G.R.Smith and MJE Sternberg, Curr Opion Struct Biol, 12, 28 (2002) - obviously a little old now. See also the CAPRI assessment http://capri.ebi.ac.uk/ These methods will give you a surfeit of predictions, the fun is in choosing the one you like, e.g. using tools like PISA HTH Martyn On Thu, 2007-11-29 at 12:47 +0000, Andreas Förster wrote: > Hey Karen, > > Pisa analyzes oligomerization interfaces. > http://www.ebi.ac.uk/msd-srv/prot_int/pistart.html > > > Andreas > > > karen yates wrote: > > Hi, > > > > I would like to find a bioinformatic tool that will allow me to predict the > > dimerisation interface of a protein. > > > > A structural model has been generated, and it is known to exist as a > > homo-dimer. > > > > Does anyone know of a suitable program? > > > > Thank you for your help. > > > > Karen > > > > > > > > ---------------------------------------------------------------- > > This message was sent using IMP, the Internet Messaging Program. > > -- *********************************************************************** * * * Dr. Martyn Winn * * * * STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, U.K. * * Tel: +44 1925 603455 E-mail: [EMAIL PROTECTED] * * Fax: +44 1925 603825 Skype name: martyn.winn * * URL: http://www.ccp4.ac.uk/martyn/ * ***********************************************************************
