Look at AP-2 alpha-appendage. And for that matter, the beta appendage too. Alpha appendage binds ~30 different proteins using two sites on one domain.
J Biol Chem. 2004 Oct 29;279(44):46191-203. Epub 2004 Aug 2. Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM. Structure. 2002 Jun;10(6):797-809. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Brett TJ, Traub LM, Fremont DH. Mol Biol Cell. 2008 Dec;19(12):5309-26. Epub 2008 Oct 8. The AP-2 adaptor beta2 appendage scaffolds alternate cargo endocytosis. Keyel PA, Thieman JR, Roth R, Erkan E, Everett ET, Watkins SC, Heuser JE, Traub LM. -Tom Tom J. Brett, PhD Assistant Professor of Medicine Division of Pulmonary and Critical Care Washington University School of Medicine Campus Box 8052, 660 S. Euclid Saint Louis, MO 63110 http://brettlab.dom.wustl.edu/ ________________________________________ From: CCP4 bulletin board [CCP4BB@JISCMAIL.AC.UK] On Behalf Of Radisky, Evette S., Ph.D. [radisky.eve...@mayo.edu] Sent: Tuesday, August 23, 2011 9:41 AM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] Is there a protein that it could interact with different proteins by the same part? This is very common among the small GTP-binding proteins of the Ras superfamily. For an interesting analysis (although doubtless there are lots of more recent examples) you might look at: Corbett and Alber, TIBS 26 (12) 710-716 (2001) Evette S. Radisky, Ph.D. Assistant Professor Mayo Clinic Cancer Center Griffin Cancer Research Building, Rm 310 4500 San Pablo Road Jacksonville, FL 32224 (904) 953-6372 -----Original Message----- From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Yamei Yu Sent: Tuesday, August 23, 2011 9:45 AM To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] Is there a protein that it could interact with different proteins by the same part? HI all, We know one protein can interact with different partners by different domains or different parts. Is there a protein that it could interact with different proteins by the same part (maybe the same part but in different conformations?)? Thank you in advance!! yamei
