Dear Colleagues,
We have an Industrial CASE BBSRC PhD Studentship on offer at the University
of Reading. Please circulate this email to relevant colleagues and UG
students.
The CASE award is a collaborative project in the Schools of Food and
Nutritional Sciences and Biological Sciences. The project title is
"Understanding the structure-function relationships of cold-adapted
enzymes".
The aim of this project is to use advanced protein engineering
methodologies to develop cold adapted enzymes that can be quickly
inactivated at temperatures less than 50oC. This work will use
computational and structural biology approaches to aid understanding of
structure, function and stability of cold adapted enzymes of commercial
importance to our industrial partner. Using this knowledge, the structural
and functional characteristics will be further enhanced, through protein
engineering, targeting the development of enzymes that have high activity
but can be quickly inactivated at low temperatures. The engineered enzymes
will be experimentally analysed using a variety of biophysical techniques
and their structures determined to verify the predictions. The enzymes will
then be characterised, with particular emphasis on the specificity of the
enzymes deactivation kinetics, and will then be evaluated regarding their
commercial potential using a variety of substrates. The PhD candidate will
develop expertise in a range of methodologies including enzymology, protein
engineering, protein expression, fermentation, purification, chromatography
and structural biology. The applicants should ideally have some experience
in protein expression and/or protein structure and some knowledge of food
biotechnology.
Funding Details: The studentship will cover Home/EU Fees and pay a tax-free
stipend of £15,226 per year for a period of up to 4 years. The studentship
will begin in October 2013.
Applicants should hold a minimum of a UK Honours Degree at 2:1 level or
equivalent.
Please note that due to restrictions on the funding, this studentship is
for UK/EU applicants only.
To be eligible for support, applicants must be 'UK Residents' as defined by
the BBSRC; this includes EU citizens who have been resident in the UK for a
period of 3 years for any purpose, including undergraduate studies, prior
to the start of the studentship.
To apply for this studentship please submit an application for a PhD in
Food Science/Applied Biochemistry to the University of Reading at:
http://www.reading.ac.uk/graduateschool/prospectivestudents/gs-how-to-apply.aspx
Please quote the reference GS13-22 in the 'Scholarships applied for' box
which appears within the Funding Section of your online application.
Application Deadline: Friday, 22 March 2013
For further information please contact:
Dr. Dimitris Charalampopoulos (d.charalampopou...@reading.ac.uk)
Dr Kim Watson (k.a.wat...@reading.ac.uk)
