You are invited to apply for a postdoctoral position in the structural biology
lab of McArdle Cancer Institute of University of Wisconsin at Madison. We are
interested in understanding the structural basis of protein phosphatase 2A
(PP2A) regulation and its cross-talk to cellular and viral kinases in
controlling signaling proteins involved in cell cycle, DNA damage response, and
cell metabolism. One important aspect of the study is to elucidate mechanisms
of protein chaperones in modulating the function of diverse PP2A complexes,
kinases and nuclear receptors in response to cellular and environmental signals
using structural biology techniques in combination of biochemical and
biophysical methods and cell biology approaches. Initial results of this
specific aspect of study can be found in our recent publications (Nat. Commun.,
4:1699, 2013; Molecular Cell 41, 1–12, 2011).
The lab is equipped with a state-of-the-art setup for x-ray crystallographic
studies, including crystallography robot, and have convenient monthly access to
powerful x-ray beamlines at APS. The researcher will work in a
multidisciplinary setup, including cell biology, biophysics, proteomics, and
protein biochemistry, in addition to protein crystallography.
Candidates should hold a PhD in protein biochemistry and crystallography and
have a good working knowledge of molecular biology techniques. The candidates
should be highly motivated, goal-driven, and dedicated individuals who can
think critically and work both independently and collaboratively with good
verbal and written communication skills. It is also important that the
candidates are creative in problem solving and have a strong desire to seek
answers to questions related to the molecular basis of cellular processes.
Experience in cell culture techniques and writing scientific research papers
would be advantageous. Eligibility to training grant is appealing, but not
essential.
This is a full-time position with a starting salary of $39,264 – 44,340 per
year depending on skills and experience.
Review of applications will begin immediately and continue until the positions
are filled.
To apply: Please send a cover letter, CV and the names and contact information
for three references to Dr. Yongna Xing, 1400 University Avenue, McArdle
Laboratory for Cancer Research, University of Wisconsin-Madison-Madison, WI
53706. Email: yx...@oncology.wisc.edu.
