Hi, In my experience, additive screens (e.g Hampton's) can change crystal morphology. You could also re-screen for new conditions either using matrix micro seeding, or change the protein buffer. Perhaps adding a ligand or a component from your current crystallisation conditions to your protein stock?
HTH, Dave On Fri, 24 Apr 2015 04:02 Prerana G. <tracy...@gmail.com> wrote: > Dear all, > > I am working on a protein (40kDa) which forms very thin plate shaped > crystals which diffracts at very low resolution. Protein concentration that > i have used for crystallisation is approx. 8mg/ml. I have attached the > picture of the protein crystal. > > > How can I improve upon the shape of the crystal? >
