*Deadline Sunday 20 January 2019*. The theme for the MRC IMPaCT programme is complex disease. This project studies membrane protein complexes relevant to fibrosis, and funding is for 3.5 years. It will be based within LISCB (Leicester Institute for Structural & Chemical Biology), and is a partnership with NIHR Leicester BRC-Respiratory, and the Membrane Protein Lab at Diamond/Harwell. Prospective applicants are encouraged contact *Bibek Gooptu*
/Andrew Quigley to discuss and can access the application form via this link (one among various listed projects): https://more.bham.ac.uk/mrc-impact/phd-opportunities/ Converting insult into injury: Cellular and structural biology studies of a macromolecular complex that links inflammation with scarring in fibrotic disease Supervisors: Bibek Gooptu (UoL) and and Andrew Quigley (Diamond) 45% of deaths in the developed world arise as a result of fibrosis – replacement of normal tissue with scar. Fibrosis is a basic response to severe or sustained insult. If confined, fibrosis can limit further tissue damage, but when widespread it leads to organ failure, cancer risk, and death. We study how different insults cause fibrosis, focusing on lung and liver disease. We have recently identified a molecular complex that represents a junction between acute inflammation and chronic scarring pathways, and may be an important target for future drug therapies. This project will use state-of-the-art cellular and structural biology approaches to understand the molecular details of how the complex assembles, works, and may be targeted by drugs. It will be studied in the context of intracellular (glycoprotein misfolding) and extracellular (bacterial molecule) insults. The work is excitingly cross-disciplinary (membrane protein crystallography, cryo-EM, cell biology, and integration within clinical/translational studies). It is also cross-institutional (Leicester Institute of Structural and Chemical Biology, NIHR Leicester BRC, Research Complex at Harwell, Diamond Light Source). The supervisors span these institutions and areas of expertise, from clinical to atomic resolution studies, and can offer outstanding training and support. Posted on behalf of *Bibek Gooptu **Professor of Respiratory Biology, LISCB and NIHR BRC-Respiratory, University of Leicester* * Consultant in Respiratory Medicine, Glenfield Hospital* *Please do not reply to me, I'm not very good at looking after this account -Peter* ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
