The Institute of Cancer Research (ICR), London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The ICR leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment. Together with our hospital partner The Royal Marsden, we are rated in the top four centres for cancer research and treatment worldwide. As well as being a world-class institute, we are a college of the University of London. We came top in the league table of university research quality compiled from the Research Excellence Framework and second in 2021 (REF 2014 and 2021). The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.
The Centre for Cancer Drug Discovery (CCDD), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CCDD’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, structural biology, assay scientists, drug metabolism and clinical specialists. This is an exciting and fast-moving research setup and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment. Two Higher Scientific Officer positions in recombinant protein purification are available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CCDD (see the links below). The team uses biochemical and biophysical assays to perform small-molecule high-throughput screening and fragment-based hit discovery, coupled with X-ray crystallography to enable structure-based drug design. These methodologies are underpinned by state-of-the art protein expression, purification and biophysical characterisation capabilities, allowing for the generation of large quantities of high-quality protein targets. We are seeking highly motivated scientists to join the team, with expertise in protein expression, protein purification and biophysics. The successful candidates will be carrying out protein expression and purification as part of the CCDD’s research programmes and will be responsible for establishing biophysical assays such as Surface Plasmon Resonance (SPR), Thermal Shift Assay (TSA) and ligand-observed NMR (LO-NMR) to characterise these protein targets and their protein-protein and protein-ligand interactions. The HSOs will be integral members of multidisciplinary project teams within the CCDD at the ICR Sutton site, and will interact closely with biologists, computational chemists, medicinal chemists, assay scientists and structural biologists. Applicants must have at least a BSc in a biochemistry or related biological subject, and ideally an MSc or PhD. Experience and demonstrable skills in molecular biology, protein expression in E. coli and protein purification are essential. The starting salary will be in the range £37,050 to £45,732 p.a. inclusive (based on previous postdoctoral experience). The posts are offered on a fixed term contract of 2 years. Informal enquiries to rob.vanmontf...@icr.ac.uk<mailto:rob.vanmontf...@icr.ac.uk> or yann-vai.lebi...@icr.ac.uk<mailto:yann-vai.lebi...@icr.ac.uk>. Please DO NOT send your application to Dr van Montfort or Dr Le Bihan, but apply via the e-recruitment system on our website www.icr.ac.uk<http://www.icr.ac.uk>. For more details see the following links: Higher Scientific Officer – Protein production, purification and biophysics https://jobs.icr.ac.uk/vacancies/838/higher-scientific-officer--protein-production-purification-and-biophysics.html Experience and demonstrable skills in molecular biology, protein expression in E. coli and protein purification are essential. Demonstrable practical experience of biophysical techniques (SPR, TSA and/or LO-NMR) is desirable. Experience in protein expression in insect and/or mammalian cells is also highly desirable. Higher Scientific Officer – Protein production and purification https://jobs.icr.ac.uk/vacancies/837/higher-scientific-officer--protein-production-and-purification.html Experience and demonstrable skills in molecular biology, protein expression in E. coli and insect cells and protein purification are essential. Demonstrable practical experience of biophysical techniques (such as DLS, TSA, ITC and/or SPR) would be highly desirable. Dr. Rob van Montfort Reader in Structural Biology and Cancer Drug Discovery Team Leader Hit Discovery and Structural Design Centre for Cancer Drug Discovery, Divisions of Cancer Therapeutics and Structural Biology The Institute of Cancer Research 15 Cotswold Road Sutton SM2 5NG UK Tel: +44-(0)20-8722-4364 Email: rob.vanmontf...@icr.ac.uk<mailto:rob.vanmontf...@icr.ac.uk> The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. 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