For what it's worth, I haven't seen this on any systems I manage when  
going from 5.0.22->5.0.45, which include permutations of master-slave  
and master-master.

Is there anything useful in /var/log/mysqld.log?


> after I updated from mysql-5.0.22 CentOS 5.0 to mysqld-5.0.45 in  
> CentOS
> 5.2, mysql looses master-slave sync after one node reboots.
>     I've noticed that the slave doest not respect the informantion on
> master.info, instead, it tries to read the informantion from the  
> master
> server file inc-index.index....
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