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From: Taylor, John (JH) <[EMAIL PROTECTED]>
To: Randall, Christine (C) <[EMAIL PROTECTED]>
Subject: Study refutes Aids link to Fifties polio vaccine
Date: Wednesday, April 26, 2000 5:01 AM



http://www.telegraph.co.uk/




ISSUE 1797 Wednesday 26 April 2000





  Study refutes Aids link to Fifties polio vaccine
By Roger Highfield, Science Editor






 The origins of HIV - St Edwards University Aids Web


 The HIV daily briefing - AEGIS


 HIV Info Web


 Aids Virtual Library



  Family tree of viruses

THE theory that the Aids epidemic was created as an accidental by-product of
experiments with a polio vaccine in about 1950 has been undermined by a
study suggesting that the virus first crossed from a chimpanzee to a human
20 years earlier.
Aids, which has infected up to 40 million people, is now the leading cause
of death among adults in sub-Saharan Africa. Some claim that the disease
emerged in humans when the kidneys of chimpanzees infected with a form of
the virus were used to make a polio vaccine tested on people in the Belgian
Congo in the early Fifties. This theory, which originated in the Eighties,
has been given a new lease of life by The River, a book by Edward Hooper.

Now a genetic study of the virus, conducted by Dr Bette Korber and Dr Tanmoy
Bhattacharya in New Mexico, has shown that the last common ancestor of the
virus that caused the Aids pandemic appeared before the vaccine was
developed, in about 1930 - with "error bars" over 20 years in either
direction.

It is not possible to say, based on this analysis, whether the last common
ancestor resided in a human host or a chimpanzee, but it does undermine the
vaccine theory by suggesting that multiple strains of the Aids virus were
well established in humans by 1950, several years before the polio vaccines
were made.

Thus for the transfer to have taken place through the vaccine, and to be
consistent with their analysis, multiple strains of the virus would have
needed to have been introduced through the vaccine. Dr Korber believes this
makes the vaccine theory unlikely. The preliminary results of the study were
presented in February at a conference in San Francisco and the final data
will be published later this year in Science.

Part of the reason that many have concentrated on a post-war origin of Aids
is that the oldest specimen of HIV was found in blood taken in 1959 in
Leopoldville, now Kinshasa in the Democratic Republic of Congo, when a Bantu
man turned up at a clinic with symptoms resembling sickle-cell anaemia.

But those sceptical of the vaccine theory argue that the virus has jumped
from chimpanzees to humans many times over thousands of years and, until
this century, affected individuals had died before spreading the virus.

Additional evidence to clarify any role of the polio vaccine in the Aids
epidemic is being sought by the Wistar Institute in Philadelphia, the
research centre that made the vaccine more than 40 years ago. Wistar has
always denied that chimps were used to make it, explaining that Asian rhesus
macaques were used which do not support the monkey or human virus.

The institute has asked three laboratories in the United States and Europe
to carry out independent tests on the seed stocks for the vaccine to look
for Simian Immunodeficiency Virus, the monkey or chimp equivalent of Aids,
which had not been found by an earlier study.

Test laboratories will also use forensic methods to identify which animals
were used to make the vaccine by hunting for mitochondrial DNA, which is
most likely to be detected in the vaccine samples. Proponents of the vaccine
theory consider these tests to be crucial. As a result, a Royal Society
conference on the origins of Aids has been delayed so that the new results
can be presented.

The polio-Aids theory was one trigger for the conference, championed by the
original organiser, Prof William Hamilton of Oxford University, who died
last month of malaria-induced haemorrhage after conducting an expedition to
the Congo to find new evidence for the vaccine theory.

One of the conference's organisers, Robin Weiss, a professor of virology at
University College London, denied that the delay in holding the conference -
originally to be held next month, now rescheduled for September - had
anything to do with pressure from opponents of the theory.

The vaccine theory was first publicised in the American magazine Rolling
Stone a decade ago. It was dismissed, however, because it then claimed that
the vaccine was made using green monkeys, which are infected by a virus that
does not match the human virus. More recently, it was suggested that
chimpanzee kidneys were used, because the chimp SIV (simian immunodeficiency
virus) well matches HIV (human immunodeficiency virus).

Most scientists support the idea that both versions of the virus jumped to
humans when a hunter in Africa was infected by blood while slaughtering an
animal. Aids may have exploited the enormous social and technological
upheaval in the wake of the Second World War. Greater access to transport,
increasing population density and more frequent sexual contacts may have
been important. Large-scale vaccination campaigns, perhaps with multiple use
of non-sterilised needles, may also have spread the virus.


2 February 2000: Aids virus dated to 1930
1 February 1999: Aids started by humans eating chimps
28 December 1999: [UK News] New blood test 'will transform HIV treatment'
12 November 1999: Why drugs fail to find Aids virus in the body











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