On Tue, Jan 30, 2024 at 12:08 PM Henrik Ohrstrom <henrik.ohrst...@gmail.com> wrote:
*> Everything that works causes some form of addiction. I myself for > example are quite addicted to my glasses and also oxygen.* > OK, but most people don't mind that they are addicted to those things but most junkies wish they weren't addicted to heroin. > Of interest is side effects I already mentioned those > >* does the drug take all sorts of pain? Just inflammation pain? > Neurogenic pain? Phantom pain?* > I don't know, all I know is it operates on the peripheral nervous system not the brain and it significantly helped about 2000 people who were in pain because it was immediately after surgery. Incidentally the Pakistani family that had that rare mutation that blocked the operation of the gene the drug is based on made money by staging exhibitions where they walked on hot coals and cut themselves with knives. John K Clark See what's on my new list at Extropolis <https://groups.google.com/g/extropolis> oim ctn > > > By studying a Pakistani family that has a rare mutation that renders them > unable >> to feel pain, a small company called Vertex Pharmaceuticals has >> developed a drug, that can be taken orally, that has shown significant >> reduction in pain in two different drug studies with no clear adverse side >> effects. The drug company found that 2 genes, called Nav1.7 and Nav1.8, are >> needed for the peripheral nervous system to transmit pain messages to the >> brain, their drug works by temporarily blocking the operation of Nav1.8 >> making it unable to manufacture the protein needed to transmit such pain >> messages. In two different clinical trials, one with 1073 people who were >> in pain and one with 1118, the patients reported a significant reduction in >> pain and they experienced less nausea and fewer headaches then with >> opioids, surprisingly even less than the control patients who received >> placebos. Because the drug targets the peripheral nervous system and has >> no obvious effect on the brain it is unlikely to cause addiction. Right now >> the drug is just called "VX-548" but if it's as good as it sounds and is >> approved by the FDA it will be a huge blockbuster and I'm sure they'll >> think of a catchier name. >> >> >> >> pnm >> > > -- You received this message because you are subscribed to the Google Groups "Everything List" group. To unsubscribe from this group and stop receiving emails from it, send an email to everything-list+unsubscr...@googlegroups.com. To view this discussion on the web visit https://groups.google.com/d/msgid/everything-list/CAJPayv0r9bbxznztfy0_ReVGqfTsXFiMnwTO7iqMGD1OShaEuw%40mail.gmail.com.
