Half the biomass of the world that we can see with our eyes or with a
microscope -- consists of plants or animls. The other half consist of
bacteria and viruses and much of these are below the surface of the planet.
One of these bacteria (or an invented one) may be useful in future decades
for the production of hydrogen (a totally non-polluting and recyclable
fuel) and so save human civilisation when fossil fuels runs out. 

Bacteria may also be useful -- indeed, essential -- for the storage of
information. The DNA of a bacterium can survive unchanged (as some
'species' have in fact done) for hundreds of millions of years without any
decrement, and can survive quite strong electromagnetic attacks by solar
storms -- which can wipe electronic memories clean.

So our future is probably going to depend totally on the way we manipulate
and conserve bacteria. Here is an interesting article by Natasha McDowell
from a recent New Scientist concerning the memory use of bacteria.

>>>>
DATA STORED IN MULTIPLYING BACTERIA

Natasha McDowell

A message encoded as artificial DNA can be stored within the genomes of
multiplying bacteria and then accurately retrieved, US scientists have shown. 

Their concern that all current ways of storing information, from paper to
electronic memory, can easily be lost or destroyed prompted them to devise
a new type of memory -- within living organisms. 

"A big concern is the protection of valuable information in the case of a
nuclear catastrophe," says information technologist Pak Chung Wong, of the
Pacific Northwest National Laboratory in Washington State. The laboratory
was set up as a nuclear energy research institute. 

A similar catastrophe strikes the US in the cult television series Dark
Angel, in which a colossal electromagnetic pulse wipes out the electronic
infrastructure. "Bacteria may be an inexpensive and stable long-term means
of data storage," Wong told New Scientist . 

Small world 

The scientists took the words of the song It's a Small World and translated
it into a code based on the four "letters" of DNA. They then created
artificial DNA strands recording different parts of the song. These DNA
messages, each about 150 bases long, were inserted into bacteria such as E.
coli and Deinococcus radiourans . 

The latter is especially good at surviving extreme conditions, says Wong.
It can tolerate high temperatures, desiccation, ultraviolet light and
ionising radiation doses 1000 times higher than would be fatal to humans. 

The beginning and end of each inserted message have special DNA tags
devised by the scientists. These "sentinels" stop the bacteria from
identifying the message as an invading a virus and destroying it, says Wong. 

"The magic of the sentinel is that it protects the information, so that
even after a hundred bacterial generations we were able to retrieve the
exact message," says Wong. "Once the DNA message is in bacteria, it is
protected and can survive." And as a millilitre of liquid can contain up to
billion bacteria, the potential capacity of such a memory system is enormous. 

Spontaneous mutations 

Deinococcus is adapted to survive in extreme conditions and is consequently
very good at repairing any mutations that spontaneously arise in its DNA
code. But Huw Williams, a bacteriologist at Imperial College, London, says
that the small size of the inserted messages makes it no surprise that they
survive 100 generations intact. 

Williams thinks a greater danger than mutations changing the message is
that they could make some bugs better adapted to their environment than
others. So far, Wong and colleagues have kept the different message
colonies separate, but in future they aim to retrieve messages from a mixed
colony. 

"If you grow the colonies indefinitely, less well-adapted bacteria may be
lost over time," he says. "The question is whether you will be able to
retain all your message populations. But this is intriguing work and very
forward looking." 
>>>>
  



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Keith Hudson,6 Upper Camden Place, Bath BA1 5HX, England
Tel:01225 312622/444881; Fax:01225 447727; E-mail: [EMAIL PROTECTED]
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