And now:Ish <[EMAIL PROTECTED]> writes:

From: [EMAIL PROTECTED]

June 15, 1999

http://www.nationalpost.com/home.asp?f=990615/2726842
PESTICIDE FOUND IN AMNIOTIC FLUID BLOCKS MALE HORMONE

The first documentation of pesticides and other man-made chemicals in the 
amniotic fluid of unborn babies in amounts that could disrupt the natural 
fetal hormones was revealed Monday by a team of U.S. and Canadian 
researchers. Scientists from Cedars-Sinai Medical Center in Los Angeles, 
California, and the University of Calgary in Alberta, Canada analyzed 
amniotic fluid from 53 pregnant women from the Los Angeles area. About 30 
percent showed measurable levels of DDE, a waste product of the pesticide 
DDT. DDE binds to receptors for the male hormone testosterone, and can 
interfere with the normal effects of testosterone on a growing fetus. "The 
key factor in assessing the significance of compounds that act like hormones 
is how their concentrations relate to the naturally occurring hormones," said 
Dr. Claude Hughes, director of the Center for Women's Health at Cedars-Sinai. 
Samples with the highest DDE concentrations were nearly equal to the 
testosterone level that should be found in female fetuses, about half the 
testosterone level that should be found in male fetuses. Warren Foster, 
Ph.D., director of research and associate director of the Center for Women's 
Health, said, "With these levels of DDE present, the natural hormones will 
presumably be suppressed or blocked. It could have an effect upon the baby's 
development, such as masculinization; however, it's speculation at this 
point." Smaller detectable amounts of polychlorinated biphenyls (PCBs) and 
other man-made chemicals were measured in the samples. The researchers have 
applied for a grant to analyze amniotic fluid from 1,000 women from the Los 
Angeles area and from Hamilton, Ontario. "We want two different sites because 
there is evidence within the literature, both with my own previous studies as 
well as others, that there are regional differences in exposures," said Dr. 
Foster. "People on the West Coast typically have higher DDE exposures than 
people on the East Coast, whereas people on the East Coast may actually have 
higher PCB exposures." 


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