Hi Bill, I recall some indexing issue in NONMEM with above 40 compartments. Please try something like NCOMP=43 or greater.
Kind regards Sven Bill Denney <wden...@humanpredictions.com> schrieb am Mo. 1. Mai 2017 um 18:42: > Hi, > > I have a model with many compartments (42 different compartments are > defined). It is currently setup this way to future-proof the dataset in > case we want to combine analyses of many drugs (about 20 different drugs > with central/peripheral compartments) and several endpoints. > > In the current model, I'm only fitting the PK of one drug, so only two of > the compartments are enabled: compartments 39 and 42. After the IGNORE > statement, the data is relatively small with 400 records between 16 > subjects, and all the data are in compartment 39 (the central compartment > for the current drug). > > CMT, EVID, and MDV (along with everything else) is correctly specified. > When I run the model with CMT 39 defined by: > > COMP=(PKCENT) ; 39 central PK compartment (ug/mL) > > the model fails with the error "COMPARTMENT ASSOCIATED WITH THE PREDICTION > IS OFF" noted for all the dosing rows, but when I specify that compartment > 39 is the default observation and dose compartment (due to IV dosing), the > model works. > > COMP=(PKCENT,DEFOBS,DEFDOSE) ; 39 central PK compartment (ug/mL) > > I thought that when CMT and EVID are specified, DEFOBS and DEFDOSE are not > important. > > Does anyone know why adding DEFOBS and DEFDOSE fixed my model? > > Thanks, > > Bill > ------------------------------ > [image: Human Predictions Logo] <http://www.humanpredictions.com>*William > S. Denney, PhD* > Chief Scientist, Human Predictions LLC > +1-617-899-8123 > wden...@humanpredictions.com > > This e-mail communication is confidential and is intended only for the > individual(s) or entity named above and others who have been specifically > authorized to receive it. If you are not the intended recipient, please do > not read, copy, use or disclose the contents of this communication to > others. Please notify the sender that you have received this e-mail in > error by replying to the e-mail or by calling +1-617-899-8123. Please then > delete the e-mail and any copies of it. Thank you. >
