It could be just coding error, could you show the control stream? Thanks Leonid
> On Feb 3, 2019, at 12:44 PM, Singla, Sumeet K <sumeet-sin...@uiowa.edu> wrote: > > Hello everyone! > > I have a question. I was trying to build a 2-compartment PK model for > marijuana use in occasional and chronic smokers. Initially, I was using > providing rate constants K12 and K21 in PK block and it resulted in poor > fitting. Then, I later changed to CL,V1, V2 , Q and it resulted in proper > fitting. I was perplexed as to why I couldn’t get a proper fit by providing > rate constants? I tried to look online but couldn’t find any proper > explanation about when (or not) we should use micro constants in PK block to > define our model in NONMEM? Does anyone has any useful insights into this? > > Regards, > Sumeet Singla > Graduate Student > Dpt. of Pharmaceutics & Translational Therapeutics > College of Pharmacy- University of Iowa >
