Dear Anna, Just to answer quickly on the question directed to me: Yes, you understood it correctly.
To implement this in practice, since your NONMEM dataset only includes one level for the covariate (all subjects have the same covariate value), you will need to make a small addition to the SCM configuration file. Lets assume DIS=1 is the covariate, where 1 codes for a new indication (which was not present in the legacy data used to generate the prior), or a new subpopulation, e.g. children/adolescents, where only adults where present in the legacy data. You would then need to add this to the scm configuration file: [code] *:DIS-2=PARCOV=(1+THETA(1)) Other than that, it is also a little tricky to generate the NONMEM control stream with NWPRI on all parameters (of the base model). PsN has an automatic function for generating this code (option to update_inits), but it may be good to check manually. Best regards Jakob Jakob Ribbing, Ph.D. Senior Consultant, Pharmetheus AB Cell/Mobile: +46 (0)70 514 33 77 jakob.ribb...@pharmetheus.com www.pharmetheus.com <http://www.pharmetheus.com/> Phone, Office: +46 (0)18 513 328 Uppsala Science Park, Dag Hammarskjölds väg 36B SE-752 37 Uppsala, Sweden
