Hello everyone, I am getting the following error while running a 2-compartment PK with Emax model for heart rate for simultaneous estimation of parameters. Can anyone please help me with that? Looks like CMT=3 which is associated with heart rate is turned off. How to turn it back on? I have attached error, sample of my dataset and control stream. " 0DATA REC 3: COMPARTMENT ASSOCIATED WITH THE PREDICTION IS OFF: CMT= 3 0DATA REC 5: COMPARTMENT ASSOCIATED WITH THE PREDICTION IS OFF: CMT= 3 0DATA REC 7: COMPARTMENT ASSOCIATED WITH THE PREDICTION IS OFF: CMT= 3 0DATA REC 9: COMPARTMENT ASSOCIATED WITH THE PREDICTION IS OFF: CMT= 3"
ID TIME TIME1 AMT DV CMT MDV EVID TYPE1 TYPE3 1402 0 9:39 40000 0 1 1 1 0 1 1402 0.183333 9:50 . 271.8 1 0 0 0 1 1402 0.183333 9:50 . 11 3 0 0 1 0 1402 0.483333 10:08 . 24.6 1 0 0 0 1 1402 0.483333 10:08 . 6 3 0 0 1 0 $INPUT C EVENT=DROP ID1=DROP ID TIME TIME1=DROP AMT DV CMT MDV EVID $SUBROUTINE ADVAN3 TRANS4 $PK TVV1 = THETA(1) ;Central Volume of distribution in L V1 = TVV1*EXP(ETA(1)) TVCL = THETA(2) CL = TVCL*EXP(ETA(2)) ;Clearance TVQ = THETA(3) Q = TVQ*EXP(ETA(3)) ;Intercompartment Clearance TVV2 = THETA(4) V2 = TVV2*EXP(ETA(4)) ;Peripheral volume in L S1=V1 EMAX = THETA(5)*EXP(ETA(5)) EC50 = THETA(6)*EXP(ETA(6)) $ERROR CP = A(1)/S1 EFF= EMAX*CP/(EC50+CP) IF (CMT.EQ.1) THEN IPRED=CP Y = IPRED*(1+ERR(1)) ELSE IPRED=EFF Y= IPRED +ERR(2) ENDIF $THETA (0, 10); [V1] (0, 50); [CL] (0, 50); [Q] (0, 100); [V2] (50) ; (0.01,100) ; $OMEGA 0.16; [P] omega(1,1) 0.08; [P] omega(2,2) 0.20; [P] omega(3,3) 0.30; [P] omega(4,4) (0, 0.2) ;BSVEMAX (0.4) ; EC50 $SIGMA 0.40 ;ERR1 0.40 ;ERR2 $ESTIMATION METHOD=1 MAXEVAL=9999 SIG=3 PRINT=5 POSTHOC NOABORT MSFO=simultaneous.MSF $TABLE ID TIME DV IPRED CP PRED NOPRINT ONEHEADER FILE=mytab001 Regards, Sumeet K. Singla Ph.D. Candidate Division of Pharmaceutics and Translational Therapeutics College of Pharmacy | University of Iowa Iowa City, Iowa sumeet-sin...@uiowa.edu<mailto:sumeet-sin...@uiowa.edu> 518.577.5881
