Hi Sam, Leonid is correct, you have to turn it off and then back on again.
https://nlmixrdevelopment.github.io/RxODE/articles/RxODE-event-types.html#turning-off-compartments shows a visual example. Matt. On Fri, Nov 8, 2019 at 1:12 PM Leonid Gibiansky <lgibian...@quantpharm.com> wrote: > actually CMT=-4 turns compartment 4 off. It need to be turned on again, > see by the record with CMT=4 (positive), see > > Plasma urine example > > in Nonmem help > > Leonid > > On 11/8/2019 1:47 PM, Leonid Gibiansky wrote: > > Negative CMT (in the data set) resets compartment amounts (CMT=-4 in > > this case) > > EVID = 4 resets all system, including A(4) (if washout time was long > > and all compartments can be set to 0) > > Also, it is easy to do post-processing, subtracting Cycle 1 AUC from > > Cycle 1-2 AUC to get Cycle 2 AUC, etc. > > Hope this helps > > Leonid > > > > On 11/8/2019 12:59 PM, Sam Liao wrote: > >> Dear nmusers, > >> > >> I have a question how to reset cumulative AUC in a $DES model, where > >> DADT(4) is set up as cumulative AUC of C1. > >> > >> Because the study is a four way crossover study, the cumulative value > >> of A(4) need to rest to zero before each subsequent treatments. > >> > >> However, NONMEM do not allow setting A(4) to zero in the statement of > >> control stream. > >> > >> Is there any work around of this problem? > >> > >> Best regards, > >> > >> Sam Liao > >> > >> On 11/7/2019 7:17 AM, Farrell, Colm wrote: > >>> > >>> At ICON, it’s our people that set us apart. > >>> > >>> As a global provider of drug development solutions, our work is > >>> serious business. 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If you have received this e-mail transmission in > >>> error, please reply to the sender, so that ICON plc can arrange for > >>> proper delivery, and then please delete the message. > >>> > >>> Thank You, > >>> > >>> ICON plc > >>> South County Business Park > >>> Leopardstown > >>> Dublin 18 > >>> Ireland > >>> Registered number: 145835 > >>> > >> -- > >> Sam Liao > >> > >
