Hi Mark,
I tested your model and dataset and checked the FORM section of the FCON
file:
FORM
(E3.0,E4.0,E8.0,2E3.0,E1.0,2E6.0,E7.0,E1.0,5E6.0/2E6.0,1F2.0)
and the FDATA, first record here:
1 0 0100100134.82338.212 1.1129042.63542.63542.63542.63542.635
42.63542.635 1
It seems to be fine. Please refer to how fortran uses the format
statement to parse strings using field sizes rather than delimiters.
Best regards,
Rikard
On 2019-12-05 08:23, Mark Tepeck wrote:
Hi Nordgren and Denny,
Thanks for your tips. Here are the NONMEM script, input CSV file row
1, and FDATA row 1. I also attached the original model file, CSV input
file as well as the FDATA (not sure NMuser allows attachment) for
troubleshooting. I did observe that multiple columns from input were
combined to fewer columns in the FDATA file. I also found occasional
generation of *fdata-1* file but not sure its role.
*
*
*The input CSV file (17 columns) *
CID, TIME, CONC, AMT, DOSE, MDV, AGE, WT, SCR, ISM, CLCR,
AA, BB, CC , DD, EE, FF
1, 0 , 0, 100, 100, 1, 34.823, 38.212,
1.1129, 0 , 42.635, 42.635, 42.635, 42.635, 42.635, 42.635, 42.635
*FDATA (6 columns):* 1, 0, 0100100134.82338.212,
1.1129042.63542.63542.63542.63542.635, 42.63542.635,1
*NONMEM script:*
$PROBLEM Test Fdata
$DATA CS1_IV1EST_PAR.CSV IGNORE=C
$INPUT ID TIME DV AMT DOSE MDV AGE WT SCR ISM CLCR AA BB CC DD EE FF
$SUBROUTINE ADVAN1 TRANS2
$PK
CL = THETA(1)*EXP(ETA(1))
V= THETA(2)*EXP(ETA(2))
S1 = V
$ERROR
IPRED = F
Y=F+F*ERR(1)+ERR(2)
$THETA
(0.1,1)
(1,10,20)
$OMEGA
0.09
0.09
$SIGMA
0.09
1
$ESTIMATION METH=1 MAXEVAL=9999 PRINT=5 POSTHOC
$TABLE ID TIME DV FILE=CS1_IV1ESTFPDF.fit
I really appreciate your input.
Mark
On Tue, Dec 3, 2019 at 11:57 PM Rikard Nordgren
<rikard.nordg...@farmbio.uu.se <mailto:rikard.nordg...@farmbio.uu.se>>
wrote:
Hi,
NM-TRAN will not add columns not listed in $INPUT or
dropped/skipped to FDATA. Could that be the reason?
Best regards
Rikard Nordgren
On 2019-12-04 01:27, Mark Tepeck wrote:
Hi All,
I am using NONMEM 7.4.3. I want to confirm the right input
dataset into NONMEM. However, I found that the FDATA file can
save only around the beginning 9 columns of the original CSV
file. The ending columns (e.g., column 10-20) are either missing
or combined into a single column in the FDATA file.
I am not sure other people encountered the same problem.
Thank you,
Mark
--
Rikard Nordgren
Systems developer
Dept of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
75124 Uppsala
Phone: +46 18 4714308
www.farmbio.uu.se/research/researchgroups/pharmacometrics/
<http://www.farmbio.uu.se/research/researchgroups/pharmacometrics/>
När du har kontakt med oss på Uppsala universitet med e-post så
innebär det att vi behandlar dina personuppgifter. För att läsa
mer om hur vi gör det kan du läsa här:
http://www.uu.se/om-uu/dataskydd-personuppgifter/
E-mailing Uppsala University means that we will process your
personal data. For more information on how this is performed,
please read here: http://www.uu.se/en/about-uu/data-protection-policy
--
Rikard Nordgren
Systems developer
Dept of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
Box 591
75124 Uppsala
Phone: +46 18 4714308
www.farmbio.uu.se/research/researchgroups/pharmacometrics/
