P.S. Its online too: https://manchester.shinyapps.io/pbpk/ It can handle 50 concurrent users and will timeout after 1 hour of inactivity.
________________________________ From: Hitesh Mistry Sent: Monday, August 2, 2021 2:53 PM To: nmusers@globomaxnm.com <nmusers@globomaxnm.com> Subject: Manchester PBPK Hello NONMEM users, We (Nicola Melillo and Hitesh Mistry) would like to introduce a Shiny PBPK app entitled, "Manchester PBPK", which can be used for exploring mean bottom up PK simulations in different species. The code is kept simple and it is open-source (https://github.com/NicolaMelillo/ManchesterPBPK), so that one can easily view all the equations and how they link together to generate concentration time-profiles in different organs. It can be used for teaching but also to simply explore a new compound for which only in-vitro data is available. The code/model will be further developed based on feedback we receive over time. If others want to edit/develop aspects please feel free to do so. Enjoy, Hitesh Mistry (Division of Pharmacy, Division of Cancer Sciences, University of Manchester) Nicola Melillo (ex-Division of Pharmacy, University of Manchester)
