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Greetings:

Below is an article that appeared in a prior issue of ADHD
RESEARCH UPDATE.  The article summarizes an important study
on ADHD in girls.  As you may be aware, much of the research
on ADHD has focused on boys, so studies like this are quite
important and long overdue.

If you have been finding the information you have been receiving
about new research on ADHD to be helpful, I'd like to encourage
you to become a regular subscriber to ADHD RESEARCH UPDATE.

This is a great time to subscribe as I'm running a special 25%
savings offer through the end of May.  You can find information
about subscribing at:

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and at the end of the article below.
       
Please feel free to forward this article to others you know
who may be interested in it.  

Sincerely,

David Rabiner, Ph.D.
Duke University

==================================================================

* ADHD IN GIRLS 

One of the important shortcomings of most of the research based 
information on ADHD is that the vast majority of studies have 
been conducted solely on boys, or, have included very few girls 
in the sample.  As a result, the scientific literature on ADHD 
is almost exclusively based on male subjects. 

Recently, a study funded by the National Institute of Mental 
Health on a large group of girls both with and without ADHD was 
published in the Journal of the American Academy of Child and 
Adolescent Psychiatry (Biederman, J. et al., (1999). Clinical 
correlates of ADHD in females: Findings from a large group of 
girls ascertained from pediatric and psychiatric referral sources.   
Journal of the American Academy of Child and Adolescent Psychiatry, 
38, 966-975.  In this study, the authors examined the clinical 
correlates of ADHD in girls so that similarities and differences 
with what has been found among boys with ADHD could be ascertained.  
This study represents the largest and most comprehensive study of 
girls with ADHD that has been published to date. 

Participants in this study were girls between the ages of 6 and 18.  
There were 140 girls who had been diagnosed with ADHD based on 
structured psychiatric interviews conducted with the child's 
parent(s).  In addition, 122 girls of similar ages and other 
backgrounds who did not have ADHD were included as comparison 
subjects.  These two groups of girls were compared on a wide 
variety of characteristics so that the researchers 
could learn about the problems associated with ADHD in females 
specifically.  The major findings are summarized below. 

* Among the girls who were diagnosed with ADHD, 59% had the 
combined type (i.e. both inattentive and hyperactive/impulsive 
symptoms), 27% had the Predominantly Inattentive type, and 
only 7% had the Predominantly Hyperactive/Impulsive type. 

Overall, a significantly greater proportion of symptoms of 
inattention were present according to parents relative to either
hyperactive/impulsive symptoms. 


* Girls with ADHD were significantly more likely to be diagnosed 
with other disorders as well. 

Compared to girls without ADHD, girls with ADHD were more likely 
to be diagnosed with co-morbid conduct disorder, oppositional defiant 
disorder, mood disorders, anxiety disorders, and substance use 
disorders.  Tic disorders and enuresis (i.e. bed wetting or day-time 
wetting) were also more common in the girls with ADHD. 

Overall, 45% of the girls with ADHD were diagnosed with at least one 
other condition.  Only 4% of the girls with ADHD had more than 2 
co-morbid disorders, however. 

Although the rate of co-morbid behavior disorders in girls with 
ADHD was high, it was still no more than half of the rate that has 
been previously reported for boys.   Because disruptive behavior 
disorders are one of the main reason that children get identified 
and referred for treatment, the authors speculate that the lower 
incidence of these problems in girls with ADHD may partially 
explain the marked gender differences that are often found in 
children with ADHD who are receiving clinical treatment. 

The rate of mood and anxiety disorders in girls with ADHD was quite 
similar to what has been previously found in boys.  Contrary to what 
some have suggested, there was thus no evidence in this sample of 
children that girls with ADHD are more likely than boys to have 
problems in these areas.  There was, however, an indication that 
problems with substance use were more common among girls with ADHD 
than has been previously found to be true for boys.  For example, 
girls with ADHD were about 4 times as likely to be smokers. 


* Cognitive, school, and family functioning 

Girls with ADHD had scores on measures of intellectual functioning 
and academic achievement that were modestly lower than what was 
found in the non-ADHD girls.  They were also about 2.5 more likely 
to be diagnosed with a learning disability, more than 16 times more 
likely to have repeated a grade in school, and almost 10 times as 
likely to have been placed in a special class at school.  

It is perplexing why girls with ADHD were so much more likely to 
have repeated a grade given that the difference in the academic 
achievement test scores were, although lower, not so dramatically 
different from other girls. I think this may reflect that fact that 
achievement testing - which is done on an individual basis - tends 
to reflect the highest level of work that children are capable of.  
In many instances, this is quite a bit higher than the level that 
a child with ADHD actually performs at on a day to day basis.  So, 
these data may reflect the debilitating effect that ADHD has on a 
child's typical school performance, which can result in grade 
retention and special class placement even for children who are 
quite bright and capable. 

The parents of girls with ADHD also described their family life as 
less cohesive and reported greater amounts of conflict with their 
daughters. 

CLINICAL IMPLICATIONS 

The results of this study make clear that ADHD in girls is as 
serious a condition and has a comparably large negative impact on 
children's functioning and adjustment as it does in boys.  Overall, 
the correlates of ADHD in girls were remarkably similar to what is 
known to be true for boys.  Among the few differences found were 
that girls were less likely to be diagnosed with a co-morbid 
behavior disorder than boys (i.e. oppositional defiant disorder 
or conduct disorder) and perhaps more likely to have problems 
related to substance use.   Rates of mood and anxiety disorders, 
and impairment in academic functioning appeared to be quite 
comparable. 

The lower rates of disruptive behavior problems, along with the 
preponderance of inattentive symptoms relative to hyperactive/
impulsive symptoms, may partially explain why ADHD in girls may 
often not be recognized.  Because rates of mood and anxiety 
disorders were similar to what has been found in boys, the authors 
speculate that in conjunction with the lower levels of disruptive 
behavior and hyperactive/impulsive symptoms, this may lead 
clinicians to diagnose girls with the former types of disorders 
rather than ADHD.   As you may recall from a study recently 
reviewed in ADHD RESEARCH UPDATE, pediatricians were significantly 
more likely to diagnose boys with ADHD than girls, even when the 
problems described by parents were quite comparable. 

The authors stress that clinicians need to be aware that, despite 
their lower rates of disruptive disorders, ADHD in girls is a 
serious condition associated with impairment in multiple areas of 
children's functioning. Thus, there is no reason to assume that the 
treatment of girls with ADHD should be any less aggressive or 
comprehensive than that of boys. 

Parents need to be aware that their daughter with ADHD is at 
significantly increased risk for a variety of other conditions as 
discussed above.  In fact, in this study, almost 50% of girls 
with ADHD had at least one other diagnosable disorder.  It is thus 
essential that as is true for boys, evaluation of girls for ADHD 
take a broad look at their emotional, behavioral, social, 
and academic functioning so that a comprehensive treatment plan 
addressing all areas of important difficulty can be developed and 
implemented.  

Too often, in my opinion, even if ADHD in females is identified, 
necessary attention to areas of difficulty apart from core ADHD 
symptoms may not be targeted in a child's treatment, or may not be 
addressed in the most helpful way.  In particular, given the 
indication of possible increased risk of substance use in girls 
with ADHD, this may be an area that is especially important for 
parents to monitor. 

There are several limitations to this study that the authors 
acknowledge. First, the girls with ADHD were referred from both 
psychiatric and pediatric facilities/practitioners, and the 
degree to which they are representative of girls with ADHD in 
the general community can not be determined with any certainty.  
Thus, it is quite possible that the girls in this study were 
more impaired than would be girls with ADHD from the general 
population. 

In addition, it is clear that research on treatment specifically 
in girls with ADHD is sorely needed.  Currently, most of the 
data on both medical and non-medical treatment of ADHD is also 
based predominantly on boys.  To my knowledge, there is currently 
no clear indication of any known differential effect for various 
treatments that is specifically related to gender, but this may 
be partially because the studies that are required to carefully look 
at this issue have not really been done. As such studies are 
published, I will certainly be sure to include them in the 
newsletter. 

______________________________________________________________________

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Dear Parent:

I hope you enjoyed the article presented above.  It is an
example of the comprehensive and objective summaries of 
research on ADHD that you will receive by subscribing to
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Sincerely,

David Rabiner, Ph.D.
Licensed Psychologist
Duke University

    













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